DURICEF®(cefadroxil) is active against Gram-positive Cocci; i.e. Group A beta-hemolytic Streptococci, Streptococcus pneumoniae and Staph, aureus.3
DUI?ICEF®(cefadroxii) is generally effective in the eradication of streptococci from the Oropharynx.3
Oral Cephalosporin is a better choice for GABHS from the pharynx.4
A 10-day course of oral cephalosporin such as DURICEF®(cefadroxil) is recommended for most penicillin-allergic individuals.4
Simple once or twice daily dosage Suspension and oral drops are available in orange/pineapple flavor
DUI?ICEF®(cefadroxii) is generally effective in the eradication of streptococci from the Oropharynx.3
Oral Cephalosporin is a better choice for GABHS from the pharynx.4
A 10-day course of oral cephalosporin such as DURICEF®(cefadroxil) is recommended for most penicillin-allergic individuals.4
Bacteriologic and clinical cure rate with DURICEF* (Cefadroxil)_ A
DURICEF'(Cefadroxil) is much preferred to other broad spectrum yf antibiotics such as Cefaclor in eradicating GABHS from the pharynx.4
The overall Odds Ratio (OR) for the bacteriologic cure rate J significantly favoured cephalosporins such as DURICEF0
(Cefadroxil).5
OR: 3.02; 95% Confidence Interval [CI]: 2.49 - 3.67, the overall J OR for clinical cure rate 2.33 (95% CI: 1.84 - 2.97), significantly favoured cephalosporins such as DURICEF* (Cefadroxil).
•(Thirty five trials involving 7125 patients were included in this meta-analysis)5
DURICEF
(Cefadroxil Monohydrate, (JSP)
¦ First generation cephalosporin, active against GABHS3
¦ Is generally effective in the eradication of Streptococci from the pharynx4
¦ A 10-day course of Duricef is recommended for most pencillin-allergic individuals4
DOSAGE GUIDELINES3
| Child's weight | Drops | Suspension | Suspension |
| (Kg) | 100mg/ml | 125mg/5ml(25mg/ml) | 250mg/5ml(50mg/ml) |
| 4 | 0.5-1dropperful | - | - |
| 5 | - | 2.5-5ml | - |
| 10 | - | 5-10ml | 2.5-5ml |
| 15 | - | 7.5-15ml | 3.75-7.5ml |
| 20 | - | 10-20ml | 5-10ml |
| 25 | - | 12.5-25ml | 6.25-12.5ml |
| Adults | Infections | Capuls500mg | tablet1g |
| pharyngitis/tonsillitis | 1capsuleBid | 1Tabletod |
Simple once or twice daily dosage Suspension and oral drops are available in orange/pineapple flavor
Abbreviated Prescribing Information
Active Ingredients:
Cefadroxil. Indications:
Upper and lower respiratory infections, Skin and soft tissue infections, Genitourinary tract infections and other infections such as osteomyelitis and septic arthritis, when caused due to susceptible microorganisms.
Dosage and Administration:
The usually recommended dose in UTI, Skin and Soft tissues infections, Pharyngitis and tonsillitis and Upper and lower respiratory track infection is 1 or 2 g/day in a single dose or 2 equally divided doses. The recommended dosage for children is 25 to 50 mg/kg/day in 2 equally divided doses (every 12 hours) as indicated. For pharyngitis, tonsillitis, and impetigo the recommended daily dosage may be administered as a single dose or in two equally divided doses (every 12 hours).
Contraindication:
Hypersensitivity to cephalosporins.
Warning and Precautions:
Previous hypersensitivity reactions to DURICEF, other cephalosporins, penicillins, or other drugs. If an allergic reaction to DURICEF occurs, discontinue the drug. Serious acute hypersensitivity reactions may require emergency treatment measures. Pseudomembranous colitis has been reported with nearly all antibacterial agents, and may range from mild to life-threatening. DURICEF should be used with caution in the presence of impaired renal function. Prolonged use may result in the overgrowth of nonsusceptible organisms. Duricef should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Pregnancy and lactation:
It should be used during pregnancy only if clearly needed and also caution should be exercised when prescribing to nursing mothers.
Adverse Reactions:
Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially Candida. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Overdosage:
No treatment is required in ingestion of less than 250 mg/kg of cephalosporins (i.e., 5 to 10 times recommended dose) other than general support and observation. For amounts greater than 250 mg/kg, induce gastric emptying (emesis induction or gastric lavage).
Cefadroxil. Indications:
Upper and lower respiratory infections, Skin and soft tissue infections, Genitourinary tract infections and other infections such as osteomyelitis and septic arthritis, when caused due to susceptible microorganisms.
Dosage and Administration:
The usually recommended dose in UTI, Skin and Soft tissues infections, Pharyngitis and tonsillitis and Upper and lower respiratory track infection is 1 or 2 g/day in a single dose or 2 equally divided doses. The recommended dosage for children is 25 to 50 mg/kg/day in 2 equally divided doses (every 12 hours) as indicated. For pharyngitis, tonsillitis, and impetigo the recommended daily dosage may be administered as a single dose or in two equally divided doses (every 12 hours).
Contraindication:
Hypersensitivity to cephalosporins.
Warning and Precautions:
Previous hypersensitivity reactions to DURICEF, other cephalosporins, penicillins, or other drugs. If an allergic reaction to DURICEF occurs, discontinue the drug. Serious acute hypersensitivity reactions may require emergency treatment measures. Pseudomembranous colitis has been reported with nearly all antibacterial agents, and may range from mild to life-threatening. DURICEF should be used with caution in the presence of impaired renal function. Prolonged use may result in the overgrowth of nonsusceptible organisms. Duricef should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Pregnancy and lactation:
It should be used during pregnancy only if clearly needed and also caution should be exercised when prescribing to nursing mothers.
Adverse Reactions:
Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially Candida. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Overdosage:
No treatment is required in ingestion of less than 250 mg/kg of cephalosporins (i.e., 5 to 10 times recommended dose) other than general support and observation. For amounts greater than 250 mg/kg, induce gastric emptying (emesis induction or gastric lavage).
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