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T-Day(levocetirizine dihydrochloride)

Posted by Blog Friday, March 25, 2011


Why to prefer T-Day over other Anti -allergies?

Superior Efficacy2,3
T-Day has two times higher affinity for the H-l receptor, compared to Cetirizine 3
T-Day has better wheal inhibition as compared to Fexofenadine and Desloratadine.2
T-Day has a rapid anti - histaminic effect than Desloratadine, Fexofenadine and Ebastine.2

Safety in Patients1,2,3

T-Day according to studies has no serious side effects when compared to 1 st generation antihistamine and would not cause side effects such as (Promomethazine) which can have serious side effects (Respiratory depression, Sleep apnoea, and Sudden Infant death syndrome (SIDS)). 7<9
T-Day metabolizes less than 14% in liver as compared to Cetirizine (40% -50%). 5'6
T-Day has low Drug — Drug Interaction.1
T-Day has low volume of distribution as compared to Cetirizine, Loratadine, Fexofenadine and Desloratadine.1


Quick relief in Patients1
Both 1 st and 2nd generation antihistamines are slow in providing relief (Chlorpheneramine — 3hrs, Diphenhydramine - 2 hrs, Desloratadine and Fexofenadine — 2 hrs) 8
Whereas,T-Day is absorbed rapidly with peak plasma level reached in < 1 hr.2
Convenience
T-Day has affordable Price T-Day has convenient dosage


Brief Prescribing information:
Composition: Tablets': Each'film-coated tablets contains 5mg levocetirizine dihydrochloride. Syrup: Each 5ml syrup contains 2.5 mg levocetirizine dihydrochloride. Pharmaco-therapeutic Group: Anti allergic Agent. Therapeutic indications Levocetirrzin*.is indicated for symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis), chronic idiopathic urticaria and allergic conjunctivitis. Posology and Method of

administration: 
Adults and adolescent 12 years and above: The daily recommended dose is 5mg (1 film coated tablet or 2 teaspoons 10ml syrup).
 Elderly: Adjustment of the dose is recommended in elderly patients with compromised renal functions. Children aged 6 year to under 12 years: The daily recommended dose is 2.5mg (1/2 film coated tablet or 1 teaspoons 5ml syrup). £7de/1)c Adjustment of the dose is recommended in elderly patients with compromised renal functions. Children aged 6 months to under 6 years: The daily recommended dose is 1.25mg (1/1 film coated tablet or 1/2 teaspoons 2.5ml syrup).

Duration of use:
The duration of use depends on the type, duration and course of complaints. For hay fever 3-6 weeks and in case of short-term pollen exposure as little as one week, is generally sufficient. Clinical experience with 5 mg levocetirizine is currently available for a 6 month treatment period. For chronic urticaria and chronic allergic rhinitis, up to one year's clinical experience is available for the racemate, and up to 18 months in patient with pruritus associated with atopic dermatitis.

 Contra-indications:
History of hypersensitivity to levocetirizine or any of the other constituents of the formulation or to any piperazine derivatives. Patients with severe renal impairment at less than 10 ml/min creatinine clearance.

Warning and precautions for use: 
Precaution is recommended with intake of alcohol. Patients with rare hereditary problems of galactose intolerance, the Lapp - lactase deficiency or glucose-galactose malabsorption should not take this medicine.

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